DuBois, Pennsylvania is fortunate to have three modes of transportation available-interstate highways, rail freight lines, and air travel. Visitors, business travelers, and shippers have the option to choose the method that is most cost effective for them.

DuBois is strategically located at the intersections of several federal and state roads. Interstate 80, the main East-West corridor, has three exits for DuBois--Exits 90, 97 and 101. Route 322 is the longest highway in Pennsylvania as it cuts a diagonal path from Philadelphia in the Southeast to the Pymatuning Reservoir in the Northwest, and Route 219 is the North-South corridor.

Rail Freight has a long tradition in DuBois and the Buffalo & Pittsburgh Railroad still serves area businesses today. DuBois is one of the few places in the region that has available land, warehouse space, or commercial properties with rail access.
The DuBois Regional Airport in nearby Falls Creek offers convenient commuter service to travelers for business or pleasure as well as carrying airfreight. Both travelers and freight transport have convenient access to the airport from Interstate 80 Exit 90. The airport is designated a Foreign Trade Zone, which can eliminate or reduce import/export fees for area businesses. Shippers who import or export products internationally can receive additional information from the DuBois Regional Airport web site.